Molecular Genetic Testing In Surgical Pathology
Pfeifer, John D. (EDT)
Arber, Daniel A., M.D. (CON)
Fuller, Christine E., M.D. (CON)
Mariappan, M. Rajan, M.D., Ph.D. (CON)
Hardcover
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BOOK SUMMARY
Written by experts from Washington University School of Medicine, this text is a thorough review of the specific molecular genetic techniques that can provide diagnostically useful molecular genetic information on tissue samples--including cytogenetics, f
Submit a book reviewBOOK SYNOPSIS
Written by experts from Washington University School of Medicine, this text is a thorough review of the specific molecular genetic techniques that can provide diagnostically useful molecular genetic information on tissue samples--including cytogenetics, fluorescence in situ hybridization (FISH), PCR, electrophoresis and hybridization analysis, DNA sequence analysis, and microarrays. The first part of the book describes each technique, indicates its advantages, disadvantages, capabilities, and limitations, and systematically addresses sensitivity and specificity issues. Subsequent chapters, organized by organ system, detail the specific applications of these tests in surgical pathology. More than 150 full-color and black-and-white illustrations complement the text.
TABLE OF CONTENTS
1 Structure and Function of DNA and RNA 1
2 DNA Damage, Mutations, and Repair 29
3 Cytogenetics 58
4 Fluorescence in situ Hybridization 72
5 Polymerase Chain Reaction 86
6 Nucleic Acid Electrophoresis and Hybridization 111
7 DNA Sequence Analysis 123
8 Sensitivity and Specificity Issues 140
9 Microarrays 152
10 Clinical Testing of Patient's Specimens 171
11 Tumors of Soft Tissue and Bone 186
12 Endocrine System 232
13 Molecular Diagnostics in Hematopathology 250
14 Neural Tumors and Neuromuscular Diseases 275
15 Gastrointestinal Tract 294
16 Reproductive Organs 322
17 Urinary Tract 345
18 Skin 367
19 Lung and Mediastinum 380
20 Breast 401
21 Head and Neck 415
22 Infectious Diseases 426
23 Identity Determination 440
24 The Future 451
Appendix 1 Genetic Codes 459
Appendix 2 Amino Acids 461
Appendix 3 Summary of Recommended Nomenclature for Describing Mutations 462
Subject Index 464
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MORE BOOK INFO
ISBN: 0781747481
ISBN(13-digit): 9780781747486
Dewey Decimal: 617/.07
Library of Congress: 2005027606
Book Publisher: Lippincott Williams & Wilkins
Language: ENG
No. of Pages: 474
Paper Weight (lb): 3.54 lb
